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DDLT vs LDLT: A comprehensive comparison of liver transplant options

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A LIVER TRANPLANT: REMOVE YOUR DISEASED OR INJURED LIVER (RIGHT) AND REPLACE IT WITH A HEALTHY LIVER (LEFT).

Understanding liver transplantation: DDLT vs LDLT

A liver transplant is a life-saving surgical procedure in which a diseased or injured liver is removed and replaced with a healthy liver. When medical treatments such as medications, endoscopy, or IV therapies are no longer effective, liver transplantation becomes the best option for survival.

Patients and families are usually offered two types of liver transplant options

  • DDLT – Deceased Donor Liver Transplantation
  • LDLT – Living Donor Liver Transplantation

Understanding the differences between DDLT and LDLT is crucial for making an informed decision that best suits the patient’s medical condition and personal circumstances.

Why understanding the differences matters

Liver transplantation decisions can significantly impact

  • Survival outcomes
  • Waiting time
  • Cost of treatment
  • Risk to the patient and donor
  • Quality of life post-transplant

Although the transplant team makes the final decision, being well-informed allows patients and their families to understand their options and participate meaningfully in choosing the best outcomes.

What is DDLT (Deceased donor liver transplantation)?

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Deceased donor liver transplantation (DDLT) involves transplanting a whole liver from a brain-dead donor whose heart is still functioning. After obtaining consent from the donor’s family, the liver is retrieved and transplanted into a recipient with end-stage liver disease.

Key features of DDLT

  • Donor source: Brain-dead donor (usually a stranger)
  • Liver used: Entire liver
  • Timing: Dependent on donor availability
  • Waiting period: Often long, especially in countries with low organ donation rates

What is LDLT (Living donor liver transplantation)?

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Living donor liver transplantation (LDLT) involves transplanting a portion of the liver from a healthy living donor, usually a close family member such as a parent, spouse, sibling, or child. Either the right or left lobe of the liver is donated.

The liver has a unique ability to regenerate. Within about three months, the donor’s and recipient’s livers undergo regeneration, restoring themselves to near-normal size and function.

Key features of LDLT

  • Donor source: Living family member
  • Liver used: Partial liver (right or left lobe)
  • Timing: Planned and elective surgery
  • Waiting period: Minimal or none

Key differences between DDLT and LDLT

ASPECT DDLT LDLT
Donor source Brain-dead donor (stranger) Living family member
Liver size Full liver transplanted Partial liver transplanted (right/left lobe)
Timing Dependent on donor availability (waiting period) Planned, reducing waitlist mortality
Surgical risk Standard liver surgery Technically more complex, longer surgery

Advantages of LDLT (Living donor liver transplant)

1. Timely transplant

Surgery can be scheduled early, preventing deterioration of the patient’s condition.

2. Reduced waiting list mortality

Especially beneficial in regions where deceased donor organs are scarce.

3. Ideal for liver cancer patients

Patients with hepatocellular carcinoma (HCC) often have low MELD scores and may not receive a deceased donor organ in time.

4. Preferred option for paediatric liver transplant

The liver size can be tailored to fit infants and children.

Disadvantages of LDLT

Technically complex surgery

LDLT is more challenging and requires highly experienced transplant surgeons.

Risk to the donor

Although minimal, donors face surgical risks such as infection, bleeding, or bile leaks.

Disadvantages of DDLT

High waiting list mortality

Patients may worsen or die while waiting for an organ.

Higher overall cost

DDLT is generally more expensive than LDLT.

Risk of infection transmission

Limited evaluation time for deceased donor organs may increase infection risk.

The role of insulated coolers in organ transport

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During organ transport, insulated medical coolers play a critical role in preserving the donor liver. These coolers

The liver is placed inside the insulated container with ice packs to ensure viability until transplantation.

  • Maintain optimal temperature
  • Control humidity
  • Protect the organ from damage

In a nutshell

Choosing between DDLT and LDLT

Both DDLT and LDLT are proven, life-saving liver transplant options.

  • DDLT avoids donor risk but involves longer wait times, higher costs, and uncertainty.
  • LDLT offers a timely, planned transplant with excellent outcomes but requires a healthy donor and advanced surgical expertise.

The best choice depends on:

  • Patient’s medical condition
  • Availability of a suitable donor
  • Local organ donation rates
  • Expert medical advice from a transplant centre

At KD Hospital, the dedicated Liver Transplant Team combines advanced technology, multidisciplinary expertise, and streamlined clinical protocols to ensure high efficiency, safety, and optimal patient outcomes in both DDLT and LDLT procedures.

Always consult a qualified liver transplant specialist to determine the most appropriate option.

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